Mice Chronically Infected with Chimeric HIV Resist Peripheral and Brain Superinfection: A Model of Protective Immunity to HIV
Identifieur interne : 002544 ( Main/Exploration ); précédent : 002543; suivant : 002545Mice Chronically Infected with Chimeric HIV Resist Peripheral and Brain Superinfection: A Model of Protective Immunity to HIV
Auteurs : Jennifer L. Kelschenbach [États-Unis] ; Manisha Saini [États-Unis] ; Eran Hadas [États-Unis] ; Chao-Jiang Gu [États-Unis] ; Wei Chao [États-Unis, Niger] ; Galina Bentsman [États-Unis] ; Jessie P. Hong [Royaume-Uni] ; Tomas Hanke [Royaume-Uni] ; Leroy R. Sharer [États-Unis] ; Mary Jane Potash [États-Unis] ; David J. Volsky [États-Unis]Source :
- Journal of Neuroimmune Pharmacology [ 1557-1890 ] ; 2012-06-01.
English descriptors
- KwdEn :
Abstract
Abstract: Infection by some viruses induces immunity to reinfection, providing a means to identify protective epitopes. To investigate resistance to reinfection in an animal model of HIV disease and its control, we employed infection of mice with chimeric HIV, EcoHIV. When immunocompetent mice were infected by intraperitoneal (IP) injection of EcoHIV, they resisted subsequent secondary infection by IP injection, consistent with a systemic antiviral immune response. To investigate the potential role of these responses in restricting neurotropic HIV infection, we established a protocol for efficient EcoHIV expression in the brain following intracranial (IC) inoculation of virus. When mice were inoculated by IP injection and secondarily by IC injection, they also controlled EcoHIV replication in the brain. To investigate their role in EcoHIV antiviral responses, CD8+ T lymphocytes were isolated from spleens of EcoHIV infected and uninfected mice and adoptively transferred to isogenic recipients. Recipients of EcoHIV primed CD8+ cells resisted subsequent EcoHIV infection compared to recipients of cells from uninfected donors. CD8+ spleen cells from EcoHIV-infected mice also mounted modest but significant interferon-γ responses to two HIV Gag peptide pools. These findings suggest EcoHIV-infected mice may serve as a useful system to investigate the induction of anti-HIV protective immunity for eventual translation to human beings.
Url:
DOI: 10.1007/s11481-011-9316-1
Affiliations:
- Niger, Royaume-Uni, États-Unis
- Angleterre, Oxfordshire, État de New York
- New York, Oxford
- Université Columbia, Université d'Oxford
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Hong</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe, OX3 9DS, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation></affiliation></author><author><name sortKey="Hanke, Tomas" sort="Hanke, Tomas" uniqKey="Hanke T" first="Tomas" last="Hanke">Tomas Hanke</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe, OX3 9DS, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author><author><name sortKey="Sharer, Leroy R" sort="Sharer, Leroy R" uniqKey="Sharer L" first="Leroy R." last="Sharer">Leroy R. 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Volsky</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Virology Division, St. Luke’s-Roosevelt Hospital Center, 432 West 58th Street, Antenucci Research Building, Room 709, 10019, New York, NY</wicri:regionArea><wicri:noRegion>NY</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology & Cell Biology, Columbia University, 10032, New York, NY</wicri:regionArea><orgName type="university">Université Columbia</orgName><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimmune Pharmacology</title><title level="j" type="abbrev">J Neuroimmune Pharmacol</title><idno type="ISSN">1557-1890</idno><idno type="eISSN">1557-1904</idno><imprint><publisher>Springer US; http://www.springer-ny.com</publisher><pubPlace>Boston</pubPlace><date type="published" when="2012-06-01">2012-06-01</date><biblScope unit="volume">7</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="380">380</biblScope><biblScope unit="page" to="387">387</biblScope></imprint><idno type="ISSN">1557-1890</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1557-1890</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptive immune responses</term><term>Brain</term><term>Chimeric HIV</term><term>HIV neuropathogenesis</term><term>Mouse model</term><term>Superinfection</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Infection by some viruses induces immunity to reinfection, providing a means to identify protective epitopes. To investigate resistance to reinfection in an animal model of HIV disease and its control, we employed infection of mice with chimeric HIV, EcoHIV. When immunocompetent mice were infected by intraperitoneal (IP) injection of EcoHIV, they resisted subsequent secondary infection by IP injection, consistent with a systemic antiviral immune response. To investigate the potential role of these responses in restricting neurotropic HIV infection, we established a protocol for efficient EcoHIV expression in the brain following intracranial (IC) inoculation of virus. When mice were inoculated by IP injection and secondarily by IC injection, they also controlled EcoHIV replication in the brain. To investigate their role in EcoHIV antiviral responses, CD8+ T lymphocytes were isolated from spleens of EcoHIV infected and uninfected mice and adoptively transferred to isogenic recipients. Recipients of EcoHIV primed CD8+ cells resisted subsequent EcoHIV infection compared to recipients of cells from uninfected donors. CD8+ spleen cells from EcoHIV-infected mice also mounted modest but significant interferon-γ responses to two HIV Gag peptide pools. These findings suggest EcoHIV-infected mice may serve as a useful system to investigate the induction of anti-HIV protective immunity for eventual translation to human beings.</div></front></TEI><affiliations><list><country><li>Niger</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Oxfordshire</li><li>État de New York</li></region><settlement><li>New York</li><li>Oxford</li></settlement><orgName><li>Université Columbia</li><li>Université d'Oxford</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Kelschenbach, Jennifer L" sort="Kelschenbach, Jennifer L" uniqKey="Kelschenbach J" first="Jennifer L." last="Kelschenbach">Jennifer L. Kelschenbach</name></noRegion><name sortKey="Bentsman, Galina" sort="Bentsman, Galina" uniqKey="Bentsman G" first="Galina" last="Bentsman">Galina Bentsman</name><name sortKey="Chao, Wei" sort="Chao, Wei" uniqKey="Chao W" first="Wei" last="Chao">Wei Chao</name><name sortKey="Gu, Chao Jiang" sort="Gu, Chao Jiang" uniqKey="Gu C" first="Chao-Jiang" last="Gu">Chao-Jiang Gu</name><name sortKey="Gu, Chao Jiang" sort="Gu, Chao Jiang" uniqKey="Gu C" first="Chao-Jiang" last="Gu">Chao-Jiang Gu</name><name sortKey="Gu, Chao Jiang" sort="Gu, Chao Jiang" uniqKey="Gu C" first="Chao-Jiang" last="Gu">Chao-Jiang Gu</name><name sortKey="Hadas, Eran" sort="Hadas, Eran" uniqKey="Hadas E" first="Eran" last="Hadas">Eran Hadas</name><name sortKey="Kelschenbach, Jennifer L" sort="Kelschenbach, Jennifer L" uniqKey="Kelschenbach J" first="Jennifer L." last="Kelschenbach">Jennifer L. Kelschenbach</name><name sortKey="Kelschenbach, Jennifer L" sort="Kelschenbach, Jennifer L" uniqKey="Kelschenbach J" first="Jennifer L." last="Kelschenbach">Jennifer L. Kelschenbach</name><name sortKey="Potash, Mary Jane" sort="Potash, Mary Jane" uniqKey="Potash M" first="Mary Jane" last="Potash">Mary Jane Potash</name><name sortKey="Potash, Mary Jane" sort="Potash, Mary Jane" uniqKey="Potash M" first="Mary Jane" last="Potash">Mary Jane Potash</name><name sortKey="Saini, Manisha" sort="Saini, Manisha" uniqKey="Saini M" first="Manisha" last="Saini">Manisha Saini</name><name sortKey="Sharer, Leroy R" sort="Sharer, Leroy R" uniqKey="Sharer L" first="Leroy R." last="Sharer">Leroy R. Sharer</name><name sortKey="Sharer, Leroy R" sort="Sharer, Leroy R" uniqKey="Sharer L" first="Leroy R." last="Sharer">Leroy R. Sharer</name><name sortKey="Volsky, David J" sort="Volsky, David J" uniqKey="Volsky D" first="David J." last="Volsky">David J. Volsky</name><name sortKey="Volsky, David J" sort="Volsky, David J" uniqKey="Volsky D" first="David J." last="Volsky">David J. Volsky</name><name sortKey="Volsky, David J" sort="Volsky, David J" uniqKey="Volsky D" first="David J." last="Volsky">David J. Volsky</name></country><country name="Niger"><noRegion><name sortKey="Chao, Wei" sort="Chao, Wei" uniqKey="Chao W" first="Wei" last="Chao">Wei Chao</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hong, Jessie P" sort="Hong, Jessie P" uniqKey="Hong J" first="Jessie P." last="Hong">Jessie P. Hong</name></region><name sortKey="Hanke, Tomas" sort="Hanke, Tomas" uniqKey="Hanke T" first="Tomas" last="Hanke">Tomas Hanke</name><name sortKey="Hanke, Tomas" sort="Hanke, Tomas" uniqKey="Hanke T" first="Tomas" last="Hanke">Tomas Hanke</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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